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NINLARO® (ixaomib) Provides Durable Strength With Long-term* Proteasome Inhibition1-4
NINLARO is the first efficacious, all-oral triple regimen† for patients with multiple myeloma after one prior therapy.1,5,6 NINLARO has been clinically proven to provide a broad range of patients with a deep, durable response in their multiple myeloma treatment.1-3,7-9
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4.810 metr
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nord-ovest dell’Italia
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La Valle d'Aosta è la regione più piccola d'Italia, con una superficie di circa 3.200 chilometri quadrati e solo 123.000 abitanti.
Si trova nel nord-ovest dell’Italia, tra le Alpi, al confine con la Francia e la Svizzera, e con il Piemonte a sud. È una regione montuosa,
Si trova nel nord-ovest dell’Italia, tra le Alpi, al confine con la Francia e la Svizzera, e con il Piemonte a sud. È una regione montuosa,
qui ci sono le cime più alte d'Europa, come il Monte Bianco a 4.810 metri, il Monte Rosa e il Cervino.
Il clima è freddo, con inverni nevosi perfetti per sciare e estati fresche.
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La capitale è Aosta, una città antica con ponti romani e teatri.
Il paesaggio è spettacolare: ci sono valli, ghiacciai,
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Among newly diagnosed people with MPNs, those with PV report the most profound quality of life deficits.
Kyūshū y Okinawa son regiones ricas en historia
Assessing mental and emotional well-being as a routine practice helps physicians understand each patient’s comprehensive experience of PV.
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Among newly diagnosed people with MPNs, those with PV.
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Assessing mental and emotional well-being as a routine of PV.
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Among newly diagnosed people with MPNs, those with PV report the most profound quality of life deficits.
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Assessing mental and emotional well-being as a routine practice helps physicians understand each patient’s comprehensive experience of PV.
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- Unadjusted, indirect comparison for illustration only; clinical significance is not implied. Cross-trial comparisons are potentially confounded by differences in trial design and study population
- There was potential overlap‡ in study populations in Terpos et al, Hájek et al, and Minarik et al due to inclusion of patients from the same registry
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- Unadjusted, indirect comparison for illustration only; clinical significance is not implied. Cross-trial comparisons are potentially confounded by differences in trial design and study population
- There was potential overlap‡ in study populations in Terpos et al, Hájek et al, and Minarik et al due to inclusion of patients from the same registry
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Therapeutic phlebotomy, used in combination with low-dose aspirin per ELN recommendations
- Aspirin is used to reduce the risk of thrombosis
- Aspirin belongs to the class of NSAIDs, and can help reduce thrombotic risk and alleviate microvascular symptoms by preventing platelet aggregation
Therapeutic phlebotomy—in patients under 60 years of age with no prior thrombosis (low-risk PV), therapeutic phlebotomy is typically initiated as a treatment for temporary HCT reduction
*Based on a prospective, observational study of 2,510 PV patients receiving phlebotomy who were evaluated using a phlebotomy burden questionnaire.
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Trial Design
TOURMALINE-MM1 was a global, phase 3, randomized, double-blind, placebo-controlled clinical trial that evaluated the longterm* treatment with the all-oral NINLARO regimen vs Rd regimen in patients with at least one prior line of treatment.1,2
PATIENT CHARACTERISTICS
TOURMALINE-MM1 included difficult-to-treat patients—including patients with primary refractory, high-risk cytogenetics, free-light chain disease, and renal impairment.1,2
- Primary endpoint: PFS, according to 2011 IMWG criteria, was assessed every 4 weeks until disease progression by a blinded IRC and was based on central laboratory results1,2
- Key secondary endpoints: OS and OS in del(17p)1,2
- Other secondary endpoints: ORR and PFS in patients with high-risk cytogenetics§ and safety1,2
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References
1. Verstovsek S, Pemmaraju N, Reaven NL, et al. Real-world treatments and thrombotic events in polycythemia vera patients in the USA. Ann Hematol. 2023;102(3):571-581. doi:10.1007/s00277-023-05089-6. 2. Verstovsek S, Pemmaraju N, Reaven NL, et al. Real-world treatments and thrombotic events in polycythemia vera patients in the USA. Electronic Supplemental Material. Ann Hematol. 2023;102(3):571-581. doi:10.1007/s00277-023-05089-6. 3. Marchioli R, Finazzi G, Specchia G, et al. Cardiovascular events and intensity of treatment in polycythemia vera. N Engl J Med. 2013;368(1):22-33. doi:10.1056/NEJMoa1208500. 4. Poullet A, Busque L, Sirhan S, et al. Symptom burden in myeloproliferative neoplasms: clinical correlates, dynamics, and survival impact—a study of 784 patients from the Quebec MPN research group. Blood Cancer J. 2025;15(1):51. doi:10.1038/s41408-025-01234-8. 5. Randrianarisoa RMF, Ramanandafy H, Mania A, et al. Prevalence and diagnostic performance of iron deficiency in polycythemia. Hematology. 2023;28(1):2204621. doi:10.1080/16078454.2023.2204621.
Kyūshū y Okinawa son regiones ricas en historia
Kyūshū y Okinawa son regiones ricas en historia
Kyūshū y Okinawa son regiones ricas en historia
Kyūshū y Okinawa son regiones ricas en historia